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KMID : 0379520030190010073
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한국독성학회지
2003 Volume.19 No. 1 p.73 ~ p.82
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Subcutaneous Toxicity Study of Saposhnikovia divaricata (Turcz.) Schischk in Rats
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Lee Yong-Soon
Cho Sung-Dae
Ahn Nam-Shik
Jung Ji-Won
Yang Se-Ran
Park Joon-Suk
Park Ki-Su
Hong In-Sun
Seo Min-Su
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Abstract
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To evaluate influence of Saposhnikovia divaricata (Turcz.) Schischk extract on rat, Saposhnikovia divaricata (Turcz.) Schischk extract was diluted with 0.9% saline (100 mg/ml/kg, 10 mg/ml/kg, and 1 mg/ml/kg, respectively), and each of diluted test material extract was daily treated subcutaneously for 4 weeks and single-treated subcutaneously for 2 weeks. There were no significances in body weight analysis, urinary analysis, and ophthalmological test. However, in serum biochemical analysis and hematological analysis, we found some significances in high and middle dose group compared with control group. These significances in serum biochemical analysis and hematological analysis may be not induced by test material, because it was not found to be significant from control group in histopathological examination. Therefore, it was concluded that NOEL (No Observed Effect Level) of test material extract may be higher than all treatment doses used in this study, and Saposhnikovia divaricata (Turcz.) Schischk extract may be a non-toxic material.
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KEYWORD
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Saposhnikovia divaricata (Turcz.) Schischk, NOEL (No Observed Effect Level)
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